个人简介：张果，女，博士，河南大学“百人计划”高层次人才，校聘教授。

2015年毕业于南开大学，获生物化学与分子生物学硕士学位；2018年毕业于南京大学，获生物学博士学位。随后进入南京大学药学流动站从事博士后研究工作。2020年至2025年任南京大学副研究员。2025年10月加入河南大学任教。

主要从事动机行为的神经调控机制，以及情绪-动机行为互作的神经环路及机制研究。系统揭示了摄食行为可变性的神经环路与突触机制；阐明了缩胆囊素（CCK）介导摄食动机转换的环路与突触可塑性机制；解析了MPOA-PVN环路在小鼠产后抑郁中的作用及神经肽加压素的调控作用。相关成果发表在Science Advances、Cell Reports、Research、Journal of Biological Chemistry、ACS Chemical Neuroscience等高水平期刊。

主持国家自然科学基金青年基金、江苏省自然科学基金青年项目、中国博士后科学基金等科研项目。

1.Zhang G^# *, Ding X-Y^#, Romanova EV^#, Liu C-P, Barry M, Doda A, Chen Q-X, Reaver C, Jin Q-C, Rubakhin SS, Li F, Jin Y-F, Kan Y-S, Liu Y-L, Guo S-Q, Mei Y-S, Fu P, Xu J-P, Mao R-T, Liu C-Y, Zhang Y-C-F, Zhang Y-L, Chang J-H, Wu S-Q, Wang H-Y, Liu W-J, Chen P, Zhou Z, Zhou H-B*, Yu Q*, Checco JW, Sweedler JV, Cropper EC, Jing J*. Synaptic and intrinsic plasticity mediated by CCK-type signaling coordinates behavioral changes during motivational state shifts. Cell Reports. 2025, 44(8): 116049.

2.Fu P^#, Liu C-P^#, Liu C-Y, Zhang Y-C-F, Xu J-P, Mao R-T, Ding X-Y, Li F, Zhang Y-L, Yang H-L, Zhu J-N*, Zhang G*, Jing J*. The hypothalamic medial preoptic area–paraventricular nucleus circuit modulates depressive-like behaviors in a mouse model of postpartum depression. Research. 2025, 8: Article 0701.

3.Mao R-T^#, Guo S-Q^#, Zhang G^# * , Li Y-D^#, Xu J-P, Wang H-Y, Fu P, Liu C-P, Wu S-Q, Chen P, Mei Y-S, Jin Q-C, Liu C-Y, Zhang Y-C-F, Ding X-Y, Liu W-J, Romanova EV, Zhou H-B*, Cropper EC, Checco JW, Sweedler JV, Jing J*. Two C-terminal isoforms of Aplysia tachykinin-related peptide receptors exhibit phosphorylation-dependent and phosphorylation-independent desensitization mechanisms. Journal of Biological Chemistry. 2024, 300(8): 107556.

4.Wang H-Y^#, Yu K^#, Yang Z^#, Zhang G^#, Guo S-Q^#, Wang T^#, Liu D-D, Jia R-N, Zheng Y-T, Su Y-N, Lou Y, Weiss KR, Zhou H-B*, Liu F*, Cropper EC, Yu Q*, Jing J*. A single central pattern generator for the control of a locomotor rolling wave in mollusc Aplysia. Research. 2023, 6: Article 0060.

5.Zhang G^#, Yu K^#, Wang T^#, Chen T-T^#, Yuan W-D, Yang F, Le Z-W, Guo S-Q, Xue Y-Y, Chen S-A, Yang Z, Liu F*, Cropper EC, Weiss KR, Jing J*. Synaptic mechanisms for motor variability in a feedforward network. Science Advances. 2020, 6: eaba4856.

6.Zhang G, Yuan W-D, Vilim FS, Romanova EV, Yu K, Yin S-Y, Le Z-W, Xue Y-Y, Chen T-T, Chen G-K, Chen S-A, Cropper EC, Sweedler JV, Weiss KR, Jing J*. Newly identified Aplysia SPTR-gene family-derived peptides: localization and function. ACS Chemical Neuroscience. 2018, 9(8): 2041–2053.

7.Zhang G^#, Vilim FS^#, Liu D-D^#, Romanova EV^#, Yu K, Yuan W-D, Xiao H, Hummon AB, Chen T-T, Alexeeva V, Yin S-Y, Chen S-A, Cropper EC, Sweedler JV, Weiss KR, Jing J*. Discovery of leucokinin-like neuropeptides that modulate a specific parameter of feeding motor programs in the molluscan model Aplysia. Journal of Biological Chemistry. 2017, 292(46): 18775–18789.

^# Equal contribution; * Corresponding author.

讲授课程：病理生理学

联系方式：GuoZhang2025@henu.edu.cn, zhangguonanda@163.com