张果，教授，博士生导师。

2000年毕业于吉林大学，获生物化学学士学位，2005年毕业于中国协和医科大学，获细胞生物学博士学位。2006年至2013年在美国威斯康星大学麦迪逊分校、爱因斯坦医学院等单位从事博士后研究工作。2014年至2023年先后在华中科技大学和南方科技大学工作，任教授。2023年6月获聘为河南大学至善特聘教授，兼任中州实验室副主任。

主要从事肥胖及其并发症的中枢神经系统机制研究。利用基因工程小鼠，揭示了下丘脑IKKβ、Syt-4、A₁R、E-Syt3和Stim1在肥胖形成中的作用；阐明了Tak1激酶在肥胖相关的脑血管功能紊乱中的作用；发现下丘脑室旁核催产素神经元调控结直肠癌的进展，以及下丘脑IKKβ/NF-κB炎症信号通路在动物衰老过程中的作用。相关研究结果发表在Nature、Cell、Nature Neuroscience、Nature Medicine、Neuron、Nature Communications、PNAS、Cell Reports、eLife、Nature Immunology和Advanced Science等期刊上面。现为中国老年学和老年医学学会抗衰老分会委员。

代表性论文：

1. Ma K^#, Yin K^#, Li J, Ma L, Zhou Q, Lu X, Li B, Li J, Wei G, Zhang G*. The Hypothalamic Epigenetic Landscape in Dietary Obesity. Advanced Science. 2024; 11: e2306379.

2. Pan S, Yin K, Tang Z, Wang S, Chen Z, Wang Y, Zhu H, Han Y, Liu M*, Jiang M*, Xu N*, Zhang G*. Stimulation of hypothalamic oxytocin neurons suppresses colorectal cancer progression in mice. eLife. 2021; 10: e67535.

3. Chen Z, Pan S, Yin K, Zhang Y, Yuan X, Wang S, Yang S, Shen Q, Tang Y, Li J, Wang Y, Lu Y*, Zhang G*. Deficiency of ER Ca²⁺ sensor STIM1 in AgRP neurons confers protection against dietary obesity. Cell Reports. 2021; 37: 109868.

4. Zhang Y^#, Guan Y^#, Pan S^#, Yan L^#, Wang P, Chen Z, Shen Q, Zhao F, Zhang X, Li J, Li J*, Cai D*, Zhang G*. Hypothalamic extended synaptotagmin-3 contributes to the development of dietary obesity and related metabolic disorders. Proc Natl Acad Sci. 2020; 117: 20149-20158.

5. Shen Q, Chen Z, Zhao F, Pan S, Zhang T, Cheng X, Zhang L, Zhang S, Qi J, Li J, Cai D*, Zhang G*. Reversal of prolonged obesity-associated cerebrovascular dysfunction by inhibiting microglial Tak1. Nature Neuroscience. 2020; 23: 832-841.

6. Wu L^#, Meng J^#, Shen Q, Zhang Y, Pan S, Chen Z, Zhu LQ, Lu Y, Huang Y, Zhang G*. Caffeine inhibits hypothalamic A₁R to excite oxytocin neuron and ameliorate dietary obesity in mice. Nature Communications. 2017; 8: 15904.

7. Kim MS, Yan J, Wu W, Zhang G, Zhang Y, Cai D*. Rapid linkage of innate immunological signals to adaptive immunity by the brain-fat axis. Nature Immunology. 2015; 16: 525-533.

8. Zhang G^#, Li J^#, Purkayastha S^#, Tang Y^#, Zhang H^#, Yin Y, Li B, Liu G, Cai D*. Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH. Nature. 2013; 497: 211-216.

9. Purkayastha, S^#, Zhang, G^#, Cai, D*. Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-β and NF-κB. Nature Medicine. 2011; 17: 883-887.

10. Zhang G, Bai H, Zhang H, Dean C, Wu Q, Li J, Guariglia S, Meng Q, Cai D*. Neuropeptide exocytosis involving synaptotagmin-4 and oxytocin in hypothalamic programming of body weight and energy balance. Neuron. 2011; 69: 523-535.

11. Purkayastha S, Zhang H, Zhang G, Ahmed Z, Wang Y, Cai D. Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress. Proc Natl Acad Sci. 2011; 108: 2939-2944.

12. Zhang X^#, Zhang G^#, Zhang H^#, Karin M, Bai H, Cai D*. Hypothalamic IKKβ/NF-κB and ER stress link overnutrition to energy imbalance and obesity. Cell. 2008; 135: 61-73.

^# Equal contribution; * Corresponding author.

Email：gzhang@henu.edu.cn, guo.a.zhang@gmail.com