娄强，男，博士，副教授，硕士生导师。2010年博士毕业于复旦大学上海医学院教育部/卫生部医学分子病毒学重点实验室病原生物学专业；现在河南大学医学院微生物学教研室、抗体药物河南省工程实验室、河南省细胞与分子免疫学重点实验室工作；中国免疫学会成员、中国细胞生物学会成员等。2014年-2016年在美国Medical College of Georgia大学做访问学者。主要从事细菌感染、肾脏损伤与保护方面的研究，目前研究方向为压力状态下（亚砷酸盐、顺铂、热休克等）细胞生存、凋亡的反应及对microRNAs的调控。主持国家自然科学基金1项，河南省教育厅基金1项，河南大学基金3项；发表学术论文27篇，其中第一作者SCI论文5篇。
一、近年主持的主要科研项目
1. 葡萄糖影响SaeRS介导的表皮葡萄球菌自溶机制研究，国家自然科学基金联合基金，2015.01-2017.12，主持人。
2. 葡萄糖代谢影响表皮葡萄球菌持留菌生存的机制，河南大学基本科研业务费科研专项（青年科研人才种子基金），2014.03-2019.03，主持人。
3. 基因工程改造抗变异链球菌SAI/II单链抗体防治龋齿的研究14B310015，河南省教育厅项目，2014.01-2016.12，主持人。
4. 基础医学双语教学改革与建设HDXJJG2013-141，河南大学第十三批校级教学改革项目，2014.01-2016.12，主持人。
5. 表皮葡萄球菌双组分信号转导系统SaeRS调控自溶酶谱的研究2011YBZR004，河南大学科学研究基金，2011.01-2013.12，主持人。
二、代表性论文
1.Lou Q, Hu Y, Ma Y, Dong Z: Heat shock factor 1 induces Crystallin-αB to protect against cisplatin nephrotoxicity.Am J Physiol Renal Physiol2016.
2.Lou Q, Ma Y, Qu D: Two-component signal transduction system SaeRS is involved in competence and penicillin susceptibility in Staphylococcus epidermidis.J Basic Microbiol2016, 56(4):358-368.
3.Lou Q, Zhang W, Liu G, Ma Y: The C-type lectin OCILRP2 costimulates EL4 T cell activation via the DAP12-Raf-MAP kinase pathway.PLoS One2014, 9(11):e113218.
4.Lou Q, Qi Y, Ma Y, Qu D:Two component signal transduction system SaeRS positively regulatesStaphylococcus epidermidisglucose metabolism.The Scientific World Journal2014:908121.
5.Lou Q, Zhu T, Hu J, Ben H, Yang J, Yu F, Liu J, Wu Y, Fischer A, Francois Pet al: Role of the SaeRS two-component regulatory system inStaphylococcus epidermidisautolysis and biofilm formation.BMC Microbiol2011, 11:146.
6.娄强, 谢盼盼, 崔秀坤, 马远方, 胡延忠: 致白内障基因Hsf4bK65R位点突变对下游热休克蛋白表达的影响.中国病理生理杂志2015, 31(9):1699-1703.
7.娄强, 王耀辉,瞿涤, 马远方: 双组分信号转导系统saeRS对表皮葡萄球菌生存能力的影响.四川大学学报(医学版)2015, 46(1):27-30.
8.娄强, 张薇, 刘广超, 马远方: 联合应用CD3/CD28单克隆抗体对小鼠T淋巴瘤细胞EL4活化的影响.中国免疫学杂志2013, 29(6):580-583.
9.娄强, 王艳歌, 瞿涤: 表皮葡萄球菌双组分信号转导系统saeRS对相关蛋白调控的研究.西安交通大学学报(医学版）2012, 33(6):680-684.
10.娄强, 朱涛, 王家学, 吴旸, 朱玉莉, 瞿涤: 表皮葡萄球菌基因删除突变株构建方法的研究.微生物与感染2008, 3(1):11-15.
11. Cui X, Xie PP, Jia PP,Lou Q, Dun G, Li S, Liu G, Zhang J, Dong Z, Ma Y, Hu Y: Hsf4 counteracts Hsf1 transcription activities and increases lens epithelial cell survival in vitro.Biochim Biophys Acta2015, 1853(3):746-755.
12. Ma W, Zhang Y, Mu H, Qing X, Li S, Cui X,Lou Q, Ma Y, Pu H, Hu Y: Glucose regulates heat shock factor 1 transcription activity via mTOR pathway in HCC cell lines.Cell Biol Int2015, 39(11):1217-1224.
13. Li S, Ma W, Fei T,Lou Q, Zhang Y, Cui X, Qin X, Zhang J, Liu G, Dong Z, Ma Y, Song Z, Hu Y: Upregulation of heat shock factor 1 transcription activity is associated with hepatocellular carcinoma progression.Mol Med Rep2014, 10(5):2313-2321.
14. Qi YJ, Wang M, Liu RM, Wei H, Chao WX, Zhang T,Lou Q, Li XM, Ma J, Zhu H, Yang ZH, Liu HQ, Ma YF: Downregulation of 14-3-3σ correlates with multistage carcinogenesis and poor prognosis of esophageal squamous cell carcinoma.PLoS One2014, 9(4):e95386.
15. Zhang J, Ma Z, Wang J, Li S, Zhang Y, Wang Y, Wang M, Feng X, Liu X, Liu G,Lou Q, Cui X, Ma Y, Dong Z, Hu YZ: Regulation of Hsf4b nuclear translocation and transcription activity by phosphorylation at threonine 472.Biochim Biophys Acta2014, 1843(3):580-589.
16. Qi YJ, Ward DG, Pang C, Wang QM, Wei W, Ma J, Zhang J,Lou Q, Shimwell NJ, Martin Aet al:Proteomic Profiling of N-linked Glycoproteins Identifies ConA-binding Pro-cathepsin D as a Novel Serum Biomarker for Hepatocellular Carcinoma.Proteomics2014, 14(2-3):186-195.
17. 王耀辉,娄强, 陈九格, 张军, 马远方: 免疫调节因子TIPE2慢病毒载体的构建及病毒包装.中国免疫学杂志2013, 29(10):1077-1079.
18. Wu Y, Wang J, Xu T, Liu J, Yu W,Lou Q, Zhu T, He N, Ben H, Hu Jet al: The Two-Component Signal Transduction System ArlRS Regulates Staphylococcus epidermidis Biofilm Formation in an ica-Dependent Manner.PLoS One2012, 7(7):e40041.
19. 王艳鸽,娄强, 董烁: Huntington舞蹈病一家系4例遗传分析.河南大学学报（医学版）2012, 31(1):39-44.
20. Hu J, Xu T, Zhu T,Lou Q, Wang X, Wu Y, Huang R, Liu J, Liu H, Yu Fet al: Monoclonal antibodies against accumulation-associated protein affect EPS biosynthesis and enhance bacterial accumulation ofStaphylococcus epidermidis.PLoS One2011, 6(6):e20918.
21. 黄红莹,娄强, 李小红, 姬新颖, 朱江木, 张虎, 马远方:蒜油对MRSA菌株的抗菌作用及作用机制研究.中国微生态学杂志2011, 23(5):429-431.
22. 姬新颖,李涛,刘瑞敏,白慧玲,牛保华,娄强,马远方: 血流动力学新特点与冠状动脉粥样硬化发生的关系.河南大学学报(医学版)2011, 30(4):231-238.
23. Zhu T,Lou Q, Wu Y, Hu J, Yu F, Qu D: Impact of the Staphylococcus epidermidis LytSR two-component regulatory system on murein hydrolase activity, pyruvate utilization and global transcriptional profile.BMC Microbiol2010, 10:287.
24. Zhao Y, Ben H, Qu S, Zhou X, Yan L, Xu B, Zhou S,Lou Q, Ye R, Zhou Tet al: Proteomic analysis of primary duck hepatocytes infected with duck hepatitis B virus.Proteome Sci2010, 8:28.
25. Yu F, Wang L, Pan J, Yao D, Chen C, Zhu T,Lou Q, Hu J, Wu Y, Zhang Xet al: Prevalence of 16S rRNA methylase genes in Klebsiella pneumoniae isolates from a Chinese teaching hospital: coexistence of rmtB and armA genes in the same isolate.Diagn Microbiol Infect Dis2009, 64(1):57-63.
26. Yang J,Lou Q, Huang R, Shen L, Chen Z: Dorsal root ganglion neurons induce transdifferentiation of mesenchymal stem cells along a Schwann cell lineage.Neurosci Lett2008, 445(3):246-251.
27. 王家学, 朱涛,娄强,吴旸, 韩聪, 瞿涤: 表皮葡萄球菌双组分信号转导系统arlS基因生物学功能研究.中华微生物学和免疫学杂志2007,27(10): 946-953.
1.Lou Q, Dong Z: Heat shock factor 1 and crystallin-αB in cisplatin-induced renal tubular cell apoptosis and nephrotoxicity: American Society of Nephrology (ASN) Kidney Week 2015. (San Diego, USA)(Poster presentation).
2.Lou Q, Liu G, Ma Y, Hu Y: OCILRP2 costimulates T cell activation by activating MAPK signaling pathway. Front Immunol Conference Abstract: 15th International Congress of Immunology (ICI) 2013. (Italy)(Published).
3. Zhang J, Ma Z, Wang J, Li S, Zhang Y, Wang Y,Wang M, FengX, Liu X, Liu G,Lou Q, Ma Y, Dong Z and Hu Y: Regulation of Hsf4b Nuclear Translocation and Transcription Activity by Phosphorylation at Threonine 472.The Chinese society for cell biology national academic conference2013. (Wuhan, China)(Poster presentation).
4.Lou Q, Zhang W, Liu G and MaY. The role of the OCILRP2/DAP12receptor complex during mouse T cell activation.The 8th Congress of Immunology of the Chinese society for cell biology2012 (Chongqing, China)(Oralpresentation).
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