一、个人简介:
滕铁山,男,1985 年12 月出生,校聘副教授。2015年7月毕业于中国科学院武汉病毒研究所,获博士学位。2015年9月至今工作于河南大学医学院病理学教研室,主要承担病理学教学工作。
二、主要研究方向:病原生物、噬菌体
三、承担的研究项目:
(1)2016-2018,河南省高等学校重点科研项目,主持,《微生物来源天然产物的分离、鉴定及抗结核活性分析》
(2)2017-2019,河南省重点研发与推广专项,主持,《天然产物PantocinWH-1的抗结核菌活性及其分子机制研究》
四、已发表论文:
1、发表论文(第一作者或通讯作者)
(1)Fan, Xiangyu,Teng, Tieshan#,Wang, Honghai,Xie, Jianping,Biology of a novel mycobacteriophage, SWU1, isolated from Chinese soil as revealed by genomic characteristics.,J Virol,2012,86(18):10230-10231。(共同第一作者IF=5.3)
(2)Teng Tieshan#,Liu Jiafa,Wei Hongping;Anti-mycobacterial peptides: from human to phage.,Cell Physiol Biochem,2015,35(2):452-466。(IF=5.1)
(3)Teng Tieshan#;Yu Junping;Yang Hang,Wei Hongping Isolation and complete genome sequence of novel virulent mycobacteriophage, CASbig.,Virologica Sinica 2015/2(IF=2.8)
(4)Tie-Shan Teng#, Ai-ling Ji, Xin-Ying Ji, et al. Neutrophils and Immunity: From Bactericidal Action to Being Conquered [J]. Journal of Immunology Research, 2017, 2017: 1-14.(IF=3.2)
(5)Tieshan Teng#, Dongdong Wu, Guoyoing Wang.Using Information Technology to integrate pathology course and information literacy as part of instruction.2017.4(EI收录)
(6)Tieshan Teng; Gai Zhang ; Xiangyu Fan; Zhenjiang Zhang ; Lei Zhang ; Dongdong Wu ; Songjian Chen; Yanzhang Li 1; Jing Jin Complete genome sequence analysis of PS2, a novel T4-like bacteriophage that infects Serratia marcescens clinical isolates.2018Archives of Virology
(7)Teng, T.; Li, Q.; Liu, Z.; Li, X.; Liu, Z.; Liu, H.; Liu, F.; Xie, L.; Wang, H.; Zhang, L.; Wu, D.; Chen, M.; Li, Y., Characterization and genome analysis of novel Klebsiella phage Henu1 with lytic activity against clinical strains of Klebsiella pneumoniae. Archives of Virology;2019, 164, (9), 2389-2393.
(8)Wang, G.; Li, X.; Zhang, L.; Elgaili Abdalla, A.; Teng, T*.; Li, Y., Crosstalk between Dendritic Cells and Immune Modulatory Agents against Sepsis. Genes 2020, 11, (3)(通讯作者)
(9)Teng, T.; Li, X.; Zhang, L.; Li, Y., Identification and Characterization of pantocin wh-1, a Novel Cyclic Polypeptide Produced by Pantoea dispersa W18. Molecules (Basel, Switzerland) 2020, 25, (3).
(10)滕铁山,谢建平,抗结核病新药作用分子机制研究进展[J].中国药理学与毒理学杂志,2011年12月,第25卷第六期:586-590.
(11)滕铁山,王洪海,谢建平,结核分枝杆菌蛋白磷酸酶及其抑制剂研发进展[J].药学学报,2011年12月, 46(1420-1428).
(12)滕铁山,谢建平,吉爱玲,李彦章,分枝杆菌噬菌体在抗结核研究中的作用[J].中国抗生素杂志,2017年10月第42卷第10期(827-835)
(13)孙伟力,刘正国,刘子正,滕铁山*,分枝杆菌噬菌体裂解系统及其相关蛋白研究进展[J].中国病原生物学杂志,2018
(14)滕铁山,谢龙翔,谢建平;新型抗结核药物研发:微生物非常规培养与沉默基因激活策略[J].生物工程学报,2018
2、发表论文(非第一或通讯作者)
(15)Dongdong Wu, Honggang Wang,Tieshan Teng, Shaofeng Duan, Ailing Ji, Yanzhang Li;Hydrogen sulfide and autophagy: A double edged sword,Accepted 2 March 2018
(16)Lei Zhang, Wen Liu, Qun Wang, Qinpei Li,Huijuan Wang,Jun Wang,Tieshan Teng, Mingliang Chen Ailing Ji, and Yanzhang Li,New Drug Candidate Targeting the 4A1 OrphanNuclear Receptor for Medullary Thyroid Cancer Therapy Accepted 2 March 2018
(17)Xu, J.; Zhao, S.; Teng, T.; Abdalla, A. E.; Zhu, W.; Xie, L.; Wang, Y.; Guo, X., Systematic Comparison of Two Animal-to-Human Transmitted Human Coronaviruses: SARS-CoV-2 and SARS-CoV. Viruses 2020, 12, (2).
(18)Wu, D.; Li, M.; Gao, Y.; Tian, W.; Li, J.; Zhang, Q.; Liu, Z.; Zheng, M.; Wang, H.; Wang, J.;Teng, T.; Zhang, L.; Ji, X.; Xie, Z.; Ji, A.; Li, Y., Peptide V3 Inhibits the Growth of Human Hepatocellular Carcinoma by Inhibiting the Ras/Raf/MEK/ERK Signaling Pathway. Journal of Cancer 2019, 10, (7), 1693-170
(19)Wu, D.; Liu, Z.; Li, J.; Zhang, Q.; Zhong, P.;Teng,T.; Chen, M.; Xie, Z.; Ji, A.; Li, Y., Epigallocatechin-3-gallate inhibits the growth and increases the apoptosis of human thyroid carcinoma cells through suppression of EGFR/RAS/RAF/MEK/ERK signaling pathway. Cancer cell international 2019, 19, 43.
五、获得专利:
(1)《一株能够产生细菌素的分散泛菌及其筛选方法和应用》专利编号:201410777726;发明人:危宏平; 滕铁山#; 杨航; 余军平;
(2)《外泌体、其制备方法及其在制备治疗肺癌的药物中的应用》专利编号:201710285865.0贺飞,李涛,张凡,李振华,杨乐,吴东栋,滕铁山,姬新颖
六、讲授课程:病理学
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