一、个人简介：

王佳佳，男，博士研究生，讲师，校聘副教授。1985年8月出生于山西晋城。2009年本科毕业于长治学院，同年考入南开大学药学院硕士研究生，2015年博士毕业于南开大学并获得化学生物学博士学位，师从赵炜教授和王鹏教授。2016年5月至2017年6月在美国佐治亚州立大学从事博士后工作，2017年7月正式加入河南大学基础医学院。主要从事糖类小分子探针的合成及其在探索肿瘤细胞O-GlcNAc糖基化蛋白种类和位点鉴定的应用，并对其糖基化蛋白功能以及作用机制进行深入研究。

二、主要研究方向：O-GlcNAc糖基化修饰及其在肿瘤发生发展中的作用机制

三、承担的研究项目：

1.国家自然科学基金青年项目，21907022，基于糖代谢调控的四价铂-氨基己糖配合物的设计、合成及其抗前列腺癌作用机制研究，2020/01-2022/12，26万，主持；

2.第65批中国博士后科学基金面上资助，2019M652528，Pt(IV)-FGN的设计、合成及抗肿瘤活性评价，2019/09-2021/9，8万，主持；

3.河南省高等学校重点科研项目计划，20A350001，可调控糖代谢的铂类药物的开发，2020/01-2021/12，3万，主持；

4.国家大学生创新性实验训练计划项目资助，201910475011，新型O-GlcNAc糖基化小分子探针的开发，2019/05-2020/5，2万，指导教师；

5.河南省高等学校重点科研项目计划，19B150003，4deo-GlcNAc及其类似物的抗菌活性和机制研究，2019/1-2020/12，主持；

6.河南大学本科教育教学改革研究与实践项目，基于微信公众号在微生物课程中的教学改革，HDXJJG2019-54，2020/1-2020-12，0.6万，主持；

四、已发表论文：

1.Jing Li^*#,Jiajia Wang^#, Liuqing Wen, He Zhu, Shanshan Li, Kenneth Huang, Kuan Jiang, Xu Li, Cheng Ma, Jingyao Qu, Aishwarya Parameswaran, Jing Song, Wei Zhao, Peng George Wang^*, An OGA-Resistant Probe Allows Specific Visualization and Accurate Identification of O GlcNAc-Modified Proteins in Cells.ACS. Chem. Biol. 2016, 11, 3002-3006（co-first author）.

2.Jiajia Wang, Yan Nie, Yunjuan Li, Yuanyuan Hou^*, Wei Zhao, Jiagang Deng, Peng George Wang, Gang Bai,Identification of target proteins of mangiferin in mice with acute lung injury using functionalized magnetic microspheres based on click chemistry.J. Agric. Food. Chem. 2015, 63, 10013-10021.

3.Jiajia Wang, Xiaomin Wang, Yunyan Zhao, Xiaoyao Ma, Yue Wan, Zhongwei Chen, Hao Chen, Hao Gan, Jing Li, Lei Li, Peng George Wang^*, Wei Zhao^*, Synthesis and biological evaluation of D-gluconhydroximo-1, 5-lactam and its oxime-substituted derivatives as pharmacological chaperons for the treatment of Gaucher disease.Med. Chem. Comm. 2016, 7, 365-370.

4.Jiajia Wang, Harmon Greenway, Shanshan Li, Mohui Wei, Sameul J. Pollizi, Peng George Wang. Facile and stereo-selective synthesis of UDP-D-α-xylose and UDP-L-β-arabinose using UDP-sugar pyrophosphorylase.Front. Chem.2018, 6,163.

5.Shanshan Li^#,Jiajia Wang*^#, Lanlan Zang^#, Hailiang Zhu, Jianshuang Guo, Jiabin Zhang, Liuqing Wen, Yi Chen, Yanhong Li, Xi Chen, Peng George Wang* andJing Li*. Production of Glycopeptide Derivatives for Exploring Substrate Specificity of Human OGA Toward Sugar Moiety.Front. Chem.2018, 6,646.（co-first author）

6.Jiajia Wang^#, Dongzhe Zhang^#, Yinhang Wen, Xuefeng Cao, Jing Ma*, Peng George Wang*. Efficient chemoenzymatic synthesis of UDP-α-6-N3-glucose.Bioorg Med Chem Lett.2019, 29,1148-1151.（co-first author）

7.Jiajia Wang^#, Yinhang Wen^#, Lu Zheng, Biao Dou, Linrong Li, Kangkang Zhao, Na Wang, Jing Ma.Characterization of chemical profiles of pH-sensitive cleavable D-gluconhydroximo-1, 5-lactam hydrolysates by LC–MS: A potential agent for promoting tumor-targeted drug delivery.Journal of Pharmaceutical and Biomedical Analysis. 2020, 185, 113244.（co-first author）

8.Jiajia Wang, Yunyan Zhao, Wei Zhao, Peng Wang, Jing Li^*, Total synthesis of N-butyl-1-deoxynojirimycin. J. CARBOHYD CHEM. 2016, 35(8-9):445-454.

9.Jing Ma, Linrong Li, Kexin Yue, Yingguang Li, Hanfang Liu, Peng George Wang, Chaojie Wang,Jiajia Wang^⁎, Wen Luo^⁎, Songqiang Xie^⁎. Bromocoumarinplatin, targeting simultaneously mitochondria and nuclei with p53 apoptosis pathway to overcome cisplatin resistance. Bioorganic Chemistry. 2020, 99, 103768.

10.Jing Ma, Yingguang Li, Linrong Li, Kexin Yue, Hanfang Liu,Jiajia Wang*, Zhuoqing Xi, Man Shi, Sihan Zhao, Qi Ma, Sitong Liu, Shudi Guo, Jianing Liu, Lili Hou, Chaojie Wang, Peng George Wang, Zhiyong Tian* and Songqiang Xie*，A Polyamine-Based Dinitro-Naphthalimide Conjugate as Substrates for Polyamine Transporters Preferentially Accumulates in Cancer Cells and Minimizes Side Effects in vitro and in vivo；Front. Chem.2020,8,1-10.

11.Jing Ma, Hanfang Liu, Zhuoqing Xi, Jiuzhou Hou, Yingguang Li, Jie Niu, Tong Liu,Shuning Bi, Xin Wang, Chaojie Wang,Jiajia Wang*, Songqiang Xie* and Peng G. Wang.Protected and De-protectedPlatinum(IV) Glycoconjugates With GLUT1 and OCT2-Mediated Selective Cancer Targeting: Demonstrated Enhanced Transporter-Mediated Cytotoxic Properties in vitro and in vivo.Front. Chem.2018, 6, 386.

12.Shanshan Li, Bingchen Yu,Jiajia Wang, Yueqin Zheng, Huajie Zhang, Margaret J. Walker, Zhengnan Yuan, He Zhu, Jun Zhang, Peng George Wang, Binghe Wang. Biomarker-Based Metabolic Labeling for Redirected and EnhancedImmune Response.ACS. Chem. Biol.2018, 13(6):1686-1694.

13.Shanshan Li, He Zhu,Jiajia Wang, Xiaomin Wang, Xu Li, Cheng Ma, Liuqing Wen, Bingchen Yu, Yuehua Wang, Jing Li^*and Peng George Wang^*, Comparative analysis of Cu (I)-catalyzed alkyne-azide cycloaddition (CuAAC) and strain-promoted alkyne-azide cycloaddition (SPAAC) in O-GlcNAc proteomics.Electrophoresis. 2016, 37, 1431–1436.

14.Tiehai Li, Lina Guo, Yan Zhang,Jiajia Wang, Zhenxing Zhang, Jing Li, Wenpeng Zhang, Jianping Lin, Wei Zhao^*, Peng George Wang^*. Structure-activity relationships in a series of C2-substituted gluco-configured tetrahydroimidazopyridines as β-glucosidase inhibitors.Bioorgannic&Medicinal Chemistry, 2011, 19: 2136~2144.

15.Tiehai Li, Lina Guo, Yan Zhang,Jiajia Wang, Zhonghua Li, Lin Lin, Zhenxing Zhang, Lei Li, Jianping Lin, Wei Zhao^*, Jing Li^*, Peng George Wang^*. Design and synthesis of O-GlcNAcase inhibitors via ‘click chemistry’ and biological evaluations.Carbohydrate Research, 2011, 346,1083~1092.

16.Tiehai Li, Hui Ye, Xuefeng Cao,Jiajia Wang, Yonghui Liu, Lifei Zhou, Qiang Liu, Wenjun Wang, Jie Shen^*, Wei Zhao^*, Peng Wang^*. Total Synthesis of Anticoagulant Pentasaccharide Fondaparinux.ChemMedChem,2014, 9, 1071–1080.

17.Tiehai Li, Zhonghua Li, Jing Li, Jiajia Wang, Lina Guo, Peng George Wang, Wei Zhao^*. Elevation of cellular O-GlcNAcylation level by a potent and selective O-GlcNAcase inhibitor based on tetrahydroimidazopyridine scaffold.Bioorganic & Medicinal Chemistry Letters,2012,22, 6854–6857.

18.韩小见，温银行，郑路，赵康康，苏峰，马静*，王佳佳*, 代谢标记小分子探针6-炔基-2-乙酰氨基半乳糖的合成，化学研究与应用，2020, 32, 442-447.

五、讲授课程：微生物教研室，负责本科教学，讲授课程：《医学免疫学与病原微生物学》，《实验微生物学》；

六、联系方式（邮箱）：jwang577@163.com