一、个人简介

2010-2014年在湖南师范大学化学化工学院本科学习，2014-2020年在华东师范大学上海市调控生物学重点实验室生物化学与分子生物学（药物化学方向）专业硕博连读，2020年7月加入河南大学基础医学院。主要从事针对肿瘤等重大疾病的药物先导化合物的设计、合成及构效关系研究。

二、研究方向

药物化学

化学生物学

三、科研论文

1.Weikai Guo¹, Yajing Xing¹, Qiansen Zhang, Jiuqing Xie, Dongxia Huang, Haijun Gu, Peng He, Miaoran Zhou,Shifen Xu, Xiufeng Pang, Mingyao Liu,* Zhengfang Yi,*Yihua Chen*.Synthesis and Biological Evaluation of B-Cell Lymphoma 6 Inhibitors of N-phenyl-4-pyrimidinamine DerivativesBearing Potent Activities against Tumor Growth.J. Med. Chem.2020,63, 2, 676-695.Top期刊，SCI一区，IF: 6.205

2.Tingting Fan¹,Weikai Guo¹, Ting Shao, Wenbo Zhou, Pan Hu, Mingyao Liu,

Yihua Chen*,Zhengfang Yi*.Design, synthesis and evaluation ofphenylthiazole and phenylthiophenepyrimidindiamine derivatives targeting the bacterial membrane.Eur. J. Med. Chem.2020,190, 112141.（co-first author）Top期刊，SCI一区，IF: 5.572

3.Qingxiang Lin, Yuan He, Xue Wang, Yong Zhang, Meichun Hu,Weikai Guo, Yundong He, Tao Zhang, Li Lai, Zhenliang Sun, Zhengfang Yi,* Mingyao Liu,* and Yihua Chen*. Targeting Pyruvate Carboxylase by a Small Molecule Suppresses Breast Cancer Progression.Adv. Sci.2020,DOI: 10.1002/advs.201903483, Top期刊，SCI一区，IF:15.804

4.Yunqi Li, Yuan He, Ting Shao, Haixiang Pei,Weikai Guo, Dazhao Mi, Isabelle Krimm, Yuanjin Zhang, Peili Wang, Xin Wang, Mingyao Liu,* Zhengfang Yi,* Yihua Chen*. Modification and Biological Evaluation of a Series of 1,5-Diaryl- 1,2,4-triazole Compounds as Novel Agents against Pancreatic Cancer Metastasis through Targeting Myoferlin.J. Med. Chem.2019,62, 4949-4966.Top期刊，SCI一区，IF: 6.205

5.Liqiang Su, Jiahui Li, Zhen Zhou, Dongxia Huang, Yuanjin Zhang, Haixiang Pei,Weikai Guo, Haigang Wu, Xin Wang, Mingyao Liu, Cai-Guang Yang*, Yihua Chen*.Design, synthesis and evaluation of hybrid of tetrahydrocarbazole with 2,4-diaminopyrimidine scaffold as antibacterial agents.Eur. J. Med. Chem.2019,162, 203-211.Top期刊，SCI一区，IF: 5.572

6.Wenbo Zhou, Anling Huang, Yong Zhang, Qingxiang Lin,Weikai Guo, Zihua You, Zhengfang Yi, Mingyao Liu and Yihua Chen*. Design and optimization of hybrid of 2,4-diaminopyimidine and arylthiazole scaffold as anticancer cell proliferation and migration agent.Eur. J. Med. Chem.2015,96c, 269-280.Top期刊，SCI一区，IF: 5.572

四、专利

1.陈益华、刘明耀、郭伟凯、易正芳、林庆祥、张勇。一种芳香基-杂环取代的嘧啶二胺类化合物及其衍生物及其医药用途。中国发明专利号：ZL201510112092.7。

2. 陈益华、郭伟凯、谢玖清、邢雅婧、易正芳、刘明耀。一类靶向BCL6的芳香环并五元芳杂环类小分子有机化合物及其衍生物及其应用。中国发明专利申请号：201910898850.0。

3.陈益华、刘明耀、郭伟凯、邢雅婧、黄懂霞、易正芳、杜冰、张乾森。一类4-嘧啶二胺类小分子有机化合物及其衍生物及其应用。中国发明专利申请号：201710405225.9。

4. 陈益华、刘明耀、郭伟凯、邢雅婧、黄懂霞、易正芳、杜冰、张乾森。4-PYRIMIDINEDI-AMINE SMALL MOLECULAR ORGANIC COMPOUNDS AND DERIVATIVES THEREOF AND USE THEREOF.PCT/CN2018/088932

五、联系方式：wkguo_99@163.com。