一、个人简介：

陈苏，河南大学基础医学院教授、博士生导师。2019年入选河南大学“杰出人才特区支持计划”第四层次特聘教授，2022年获批河南省自然科学基金优秀青年科学基金，2023年入选河南省高等学校特聘教授，2023年被认定为河南省内一流人才（C类）。

二、主要研究方向：

围绕肿瘤等重大疾病以及细胞命运决定、细胞死亡与代谢等重要生物学过程，聚焦表观遗传调控、蛋白质降解调控、以及自噬相关蛋白的“非自噬”功能等，开展分子与细胞生物学的基础研究，以期揭示肿瘤等重大疾病的发病机理、发现新型诊疗靶标，为这些疾病的诊疗提供新的思路。

3、承担的研究项目：

作为项目负责人承担国家自然科学基金4项、河南省自然科学基金优秀青年科学基金1项、上海市自然科学基金面上项目1项、中国博士后科学基金2项。

三、已发表论文：

[13] Sheng Li§, *, Bo-Wen Zhang§, Qian-Qian Lou, Yue Liu, Zi-Juan Wei, Jing Huang, Kun-Hou Yao, Qian-Ru Xu, Juan Fan, Yan Xi, Lu Yang*, Su Chen*. (2024) ATG5 nonautophagically regulates inflammation and differentiation in mouse embryonic stem cells. Autophagy 20(8): 1897-1898. (Invited Paper，通讯作者)

[12] Sheng Li§, Jin Sun§, Bo-Wen Zhang§, Lu Yang§, Ying-Cui Wan, Bei-Bei Chen, Nan Xu, Qian-Ru Xu, Juan Fan, Jia-Ni Shang, Rui Li, Chen-Ge Yu, Yan Xi*, Su Chen*. (2024) ATG5 attenuates inflammatory signaling in embryonic stem cells to control differentiation. Developmental Cell 59(7): 882-897. (通讯作者)

[11] Jia-Ni Shang, Chen-Ge Yu, Rui Li, Yan Xi, Yue Jenny Jian, Nan Xu*, Su Chen*. (2024) The nonautophagic functions of autophagy-related proteins. Autophagy 20(4): 720-734. (Review，通讯作者)

[13] Sheng Li§, Leilei Zhang§, Guoan Zhang§, Guoqiang Shangguan, Xitan Hou, Wanglin Duan, Yan Xi, Nan Xu, Bowen Zhang, Junli Dong, Yequan Wang*, Wen Cui*, Su Chen*. (2021) A nonautophagic role of ATG5 in regulating of cell growth by targeting c-Myc for proteasome-mediated degradation. iScience 24(11): 103296. (通讯作者)

[10] Sheng Li§, Guoan Zhang§, Yanping Liu§, Qinru Sun§, Lu Yang, Junli Dong, Bowen Zhang, Su Chen*. (2021) In vitro ubiquitination and degradation of histone H2B by the nucleoli fractions. STAR Protocols 2(2): 100601. (Invited Paper，通讯作者)

[9] Yanping Liu§, Yufei Wang§, Lu Yang§, Feng Sun§, Sheng Li§, Yequan Wang, Guo-An Zhang, Tingting Dong, Lei-Lei Zhang, Wanglin Duan, Xiaojun Zhang*, Wen Cui*, Su Chen*. (2021) The nucleolus functions as the compartment for histone H2B protein degradation. iScience 24(4): 102256. (通讯作者)

[8] Yuan-Ya Jing, Feng-Feng Cai, Lei Zhang, Jing Han, Lu Yang, Fan Tang, Ya-Bin Li, Jian-Feng Chang, Feng Sun, Xiao-Mei Yang*, Fang-Lin Sun*, Su Chen*. (2020) Epigenetic regulation of the Warburg effect by H2B monoubiquitination. Cell Death and Differentiation 27(5): 1660-1676. (通讯作者)

[7] Yufei Wang§, Lu Yang§, Xiaojun Zhang§, Wen Cui*, Yanping Liu, Qin-Ru Sun, Qing He, Shiyan Zhao, Guo-An Zhang, Yequan Wang, Su Chen*. (2019) Epigenetic regulation of ferroptosis by H2B monoubiquitination and p53. EMBO Reports 20(7): e47563. (F1000Prime推荐论文，通讯作者)

[6] Xin Huang§, Lu Yang§, Feng-Feng Cai§, Yufei Wang, Ping Chen, Jiangsheng Mi, Chenghua Yu, Jianghua Lai, Xiaojun Zhang, Shuguang Wei, Wen Cui*, Su Chen*. (2017) Autophagy-related protein ATG5 regulates Histone H2B mono-ubiquitylation by translational control of RNF20. Journal of Genetic and Genomics 44(10): 503-506. (通讯作者)

[5] Su Chen*, Yuanya Jing§, Xuan Kang§, Lu Yang, Da-Liang Wang, Wei Zhang, Lei Zhang, Ping Chen, Jian-Feng Chang, Xiao-Mei Yang*, Fang-Lin Sun*. (2017) Histone H2B monoubiquitination is a critical epigenetic switch for the regulation of autophagy. Nucleic Acids Research 45(3): 1144-1158. (第一/通讯作者)

[4] Su Chen, Chen Wang, Luxi Sun, Da-Liang Wang, Lu Chen, Zhuan Huang, Qi Yang, Jie Gao, Xi-Bin Yang, Jian-Feng Chang, Ping Chen, Li Lan, Zhiyong Mao*, Fang-Lin Sun*. (2015) RAD6 promotes homologous recombination repair by activating autophagy-mediated degradation of heterochromatin protein HP1. Molecular and Cellular Biology 35(2): 406-416. (第一作者)

[3] Su Chen§, Juan Li§, Da-Liang Wang§, Fang-Lin Sun*. (2012) Histone H2B lysine 120 monoubiquitination is required for embryonic stem cell differentiation. Cell Research 22(9): 1402-1405. (第一作者)

[2] Su Chen, Da-Liang Wang, Yan Liu, Lei Zhao, Fang-Lin Sun*. (2012) RAD6 regulates the dosage of p53 by a combination of transcriptional and posttranscriptional mechanism. Molecular and Cellular Biology 32(2): 576-587. (第一作者)

[1] Su Chen, Hui-Min Wei, Wen-Wen Lv, Da-Liang Wang, Fang-Lin Sun*. (2011) E2-ligase dRad6 Regulates DMP53 Turnover in Drosophila. Journal of Biological Chemistry 286(11): 9020-9030. (第一作者)

四、讲授课程：

研究生学位课程：《生物学理论基础与前沿》

五、联系方式（邮箱等）：

chensubio@163.com

六、课题组网址：

https://www.x-mol.com/groups/chen_su